Dr. Öğr. Üyesi
SEVİL ZENCİR
TIP FAKÜLTESİ >> TEMEL TIP BİLİMLERİ >> TIBBİ BİYOLOJİ
YÖK AKADEMİK ORCID:Eğitim Bilgileri
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2005 - 2012 Doktora
EGE ÜNİVERSİTESİ
FEN BİLİMLERİ ENSTİTÜSÜ
- 2002 - 2005 Yüksek Lisans
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1997 - 2002 Lisans
EGE ÜNİVERSİTESİ
FEN FAKÜLTESİ
Araştırma Alanları
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Sağlık Bilimleri Temel Alanı
Tıbbi Biyoloji
Mesleki Deneyim
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2014 - 2014 ARAŞTIRMA GÖREVLİSİ
University of Illinois at Chicago Collage of Pharmacy
Department of Biopharmaceutical Sciences
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2012 - 2013 ARAŞTIRMA GÖREVLİSİ
Rutgers, The State University of New Jersey New Jersey Medical School
Department of Microbiology and Molecular Genetics
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2012 - ARAŞTIRMA GÖREVLİSİ
PAMUKKALE ÜNİVERSİTESİ TIP FAKÜLTESİ TEMEL TIP BİLİMLERİ BÖLÜMÜ
TIBBİ BİYOLOJİ ANABİLİM DALI
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2009 - 2012 ARAŞTIRMA GÖREVLİSİ
Dalhousie University Faculty of Medicine
Biochemistry and Molecular Biology
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2007 - 2012 ARAŞTIRMA GÖREVLİSİ
Szeged Üniversitesi Faculty of Science and Informatics Biological Research Center
Department of Biochemistry and Molecular Biology
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2005 - 2012 ARAŞTIRMA GÖREVLİSİ
EGE ÜNİVERSİTESİ FEN FAKÜLTESİ BİYOKİMYA BÖLÜMÜ
BİYOKİMYA ANABİLİM DALI
İdari Görevler
Yayınlar ve Eserler
Makaleler
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Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes
PLOS ONE
Özgün Makale Uluslararası
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Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase II
Chemical Research in Toxicology
Özgün Makale Uluslararası
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Inhibition of human DNA topoisomerase II by two novel ellipticine derivatives
Bioorganic & Medicinal Chemistry Letters
Özgün Makale Uluslararası
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The interference of piperidinopropionaphthone hydrochloride in mammalian type I and type II DNA topoisomerase reactions
MARMARA PHARMACEUTICAL JOURNAL
Özgün Makale Ulusal
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MYD88 Expression and L265P Mutation in Mature B Cell Non Hodgkin Lymphomas
Genetic Testing and Molecular Biomarkers
Özgün Makale Uluslararası
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Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition
Molecular Biology of the Cell
Özgün Makale Uluslararası
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Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication
PLOS Genetics
Özgün Makale Uluslararası
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Identification of transcriptional and phosphatase regulators asinteraction partners of human ADA3 a component of histoneacetyltransferase complexes
BIOCHEMICAL JOURNAL
Özgün Makale Uluslararası
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New partner proteins containing novel internal recognition motif for human glutaminase interacting protein hGIP
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Özgün Makale Uluslararası
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Gossypol Interferes with Both Type I and Type II TopoisomeraseActivities Without Generating Strand Breaks
CELL BIOCHEMISTRY AND BIOPHYSICS
Özgün Makale Uluslararası
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The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killingand Topoisomerase Activity
RECORDS OF NATURAL PRODUCTS
Özgün Makale Uluslararası
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The Objectivity of Reporters Interference Between Physically UnlinkedPromoters Affects Reporter Gene Expression in Transient TransfectionExperiments
DNA AND CELL BIOLOGY
Özgün Makale Uluslararası
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Imatinib induced apoptosis a possible link to topoisomerase enzymeinhibition
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Özgün Makale Uluslararası
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Oxidative Stress and Apoptosis in Relation to Exposure to Magnetic Field
CELL BIOCHEMISTRY AND BIOPHYSICS
Özgün Makale Uluslararası
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Identification of brain specific angiogenesis inhibitor 2 as aninteraction partner of glutaminase interacting protein
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Özgün Makale Uluslararası
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The mRNA Expression of Cytochrome P450 Isoforms in Human Gastric Tissue
HEPATO-GASTROENTEROLOGY
Özgün Makale Uluslararası
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Biological activity of bis benzimidazole derivatives on DNAtopoisomerase I and HeLa MCF7 and A431 cells
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Özgün Makale Uluslararası
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Synthesis and biological activity evaluation of 1H benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays
European Journal of Medicinal Chemistry
Özgün Makale Uluslararası
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Cytotoxic activity of 4 hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I
Journal of Enzyme Inhibition and Medicinal Chemistry
Özgün Makale Uluslararası
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Detection of Cytochrome P450 2A6 3A5 and 4B1 with Real Time PolymeraseChain Reaction in Prostate Tissue
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Özgün Makale Uluslararası
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No strong association between HER 2 neu protein overexpression and geneamplification in high grade invasive urothelial carcinomas
PATHOLOGY & ONCOLOGY RESEARCH
Özgün Makale Uluslararası
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H pylori iceA alleles are disease specific virulence factors
WORLD JOURNAL OF GASTROENTEROLOGY
Özgün Makale Uluslararası
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The role of RELN in lissencephaly and neuropsychiatric disease
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Özgün Makale Uluslararası
Bildiriler
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An ultracentrifugation based protocol for exosome isolation in Diffuse Large B Cell Lymphoma
Congress of the International Society for Extracellular Vesicles (ISEV2016)
Özet bildiri Uluslararası
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GCN5participates in ADA3 partnership as revealed with yeast hybrid
41st FEBS Congress
Özet bildiri Uluslararası
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Synthesis of new ellipticine derivatives and estimation of their interference on humanDNA topoisomerase reactions
41st FEBS Congress
Özet bildiri Uluslararası
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MYD88 expression and L265P mutation in mature B cell non Hodgkin lymphomas
5th International Congress on Leukemia Lymphoma Myeloma
Poster Uluslararası
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Molecular Interactions of ADA2 Proteins as the components of Histone Acetyl Transferrase Complexes
Gene Transcription in Yeast: From Regulatory Networks to Mechanisms (EMBO Conference)
Poster Uluslararası
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Biological activity evaluation of a novel Ellipticine derivative using human Topoisomerase II
Gordon Research Conference on “DNA Topoisomerases in Biology & Medicine
Poster Uluslararası
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Understanding protein protein interaction network a case study with glutaminase interacting protein
Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
Poster Uluslararası
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Binding of multiple Rap1 proteins stimulates DNA break induction during S phase
Cold Spring Harbor Laboratory Telomere and Telomerase Meeting
Sözlü Bildiri Uluslararası
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Protein Protein Interaction Analysis Modulation EMBO Workshop 6 9 06 2012 Roscoff Fransa
Yeast Hybrid Technologies as a Tool in Pharmaceutical Research
Poster Uluslararası
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What can yeast hybrit technology tell us in drug sensitivity in drug screening Its implications and limitations
Drug Research and Development, From Chemistry to Medicine
Poster Uluslararası
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Identification of New Potential Interaction Partners of Human ADA3 via Yeast Hybrid Technology
36th FEBS Congress, Biochemistry for Tomorrow's Medicine
Poster Uluslararası
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DNA Topoisomerases as a Tool for Screening Pharmacological Significance of the Synthetic Compounds and Natural Extracts
Advances in DNA Topoisomerase and Chromosome Dynamics
Poster Uluslararası
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Glutaminase Interacting Protein Interacts with Brain Specific Angiogenesis Inhibitor2 A Possible Link to Angiogenesis and Cellular Signalling
4th Asia Pacific Regional ISSX Meeting
Sözlü Bildiri Uluslararası
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The Interference of Piperidinopropionaphtone hydrochloride in DNA Topoisomerase Reactions in Relation to Cytostatic Assays
16th North American Regional ISSX Meeting
Poster Uluslararası
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Interindividual Difference in CYP2A6 Genotypes as Determined with Restrictional Fragment Length Polymorphism in Relation to GSTM1 and GSTT1 Genes Among the Patients with Prostate Carcinoma
3rd Asian Pacific Regional Meeting of the International-Society-for-the-Study-of-Xenobiotics
Poster Uluslararası
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Apoptotic and Necrotic Cell Percentages in Kidney Cells from Rats Exposed to Magnetic Field
3rd Asian Pacific Regional Meeting of the International-Society-for-the-Study-of-Xenobiotics
Poster Uluslararası
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Cytotoxic activity of 4 hydroxyhalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I
Third AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development
Poster Uluslararası
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Synthesis and biological activity evaluation of 1H benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays
Third AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development
Poster Uluslararası
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Prostat dokularında real time reverse transkriptaz PCR ile sitokrom P450 2A6 3A5 ve 4B izoformlarının belirlenmesi
VIII Ulusal Tıbbi Genetik Kongresi
Poster Ulusal
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Determination of Cytochrome P450 Isoforms Expressed in Stomach Tissue Samples
European Conference on Cancer and Ageing
Poster Uluslararası
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Expression of Cytochrome P450 2A6 3A5 and 4B1 in prostate tissue
8th International ISSX Meeting
Poster Uluslararası
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Synthesis and Kinetic Evaluation of 1H Benzimidazole as Mammalian DNA Topoisomerase I Inhibitors
8th International ISSX Meeting
Poster Uluslararası
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No strong association between HER 2 neu protein overexpression and gene amplification in high grade invasive urothelial carcinomas
6th European Cytogenetics Conference
Poster Uluslararası
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Inter individual variation in CYP2A6 genotypes in relation to lung cancer risk among habitual tobacco smokers in Turkey
31th FEBS Congress
Poster Uluslararası
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H pylori iceA alleles are disease specific virulence factors
31st Turkish Microbiology Congress
Poster Uluslararası
Kitap / Kitap Bölüm
Projeler ve Patentler
Projeler
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1 Güney Batı Anadolu da Yayılış Gösteren Onosma Türlerinden Sitotoksik Bileşiklerin Elde Edilmesi DNA Topoizomeraz Enzimleri Üzerindeki Etkilerinin Araştırılması
Danışman TÜBİTAK PROJESİ
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2 Yeni Eliptisin Türevlerinin Sentezi ve İnsan DNA Topoizomeraz Ii Enzimleri Üzerindeki Etkilerinin Karşılaştırmalı Kinetik Analizleri
Araştırmacı TÜBİTAK PROJESİ
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3 Surveillance and maintenance of DNA ends NIH 6R01CA148939 04 numaralı proje
Araştırmacı ARAŞTIRMA PROJESİ
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4 Regulatory networks in DNA damage checkpoint response NIH 6R01GM073876 09 numaralı proje
Araştırmacı ARAŞTIRMA PROJESİ
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5 Kromatin modifiye edici sistemler ve transkripsiyonun regülasyonu
Araştırmacı Avrupa Birliği
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6 Histon Asetil Transferaz Komplekslerinin Bileşenleri Olan Ada Proteinlerinin Moleküler Etkileşimlerinin Biyolojik Karakterizasyonu
Yürütücü TÜBİTAK PROJESİ
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7 Kemoterapi uygulamalarında hedeflenen insan topoizomeraz II enziminin moleküler etkileşimlerinin belirlenmesi ve protein partnerlerinin farmasötik önemlerinin değerlendirilmesi
Araştırmacı TÜBİTAK PROJESİ
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8 ADA3 proteininin transkripsiyonel regülasyondaki rolü ve diğer transkripsiyonel aktivatörlerle etkileşimleri
Bursiyer TÜBİTAK PROJESİ
Sanatsal Faaliyetler
Ödüller
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Post-Doctoral Fellowship (NIH-6R01GM073876-09 ve NIH-6R01CA148939-04 projeler kapsamında)
RUTGERS, The University of New Jersey
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Marie Curie Fellowship (EU FP-6, HPRN-CT-2004- 504228 nolu AB projesi kapsamında)
Hungarian Acedemy of Sciences, Biological Research Center
Tez Danışmanlığı
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The effects of naphthoquinones isolated from Onosma species on DNA topoisomerases and their cytotoxic properties
Mühendislik ve Fen Bilimleri Enstitüsü Biyoteknoloji Ana Bilim Dalı