Öğr. Gör.
ÖZDEN ÖZGÜN ACAR
DENİZLİ SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU
YÖK AKADEMİK ORCID: 0000-0002-2910-6349Eğitim Bilgileri
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2013 - 2017 Doktora
PAMUKKALE ÜNİVERSİTESİ
FEN BİLİMLERİ ENSTİTÜSÜ
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2009 - 2012 Yüksek Lisans
PAMUKKALE ÜNİVERSİTESİ
FEN BİLİMLERİ ENSTİTÜSÜ
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2005 - 2009 Lisans
PAMUKKALE ÜNİVERSİTESİ
FEN-EDEBİYAT FAKÜLTESİ
Araştırma Alanları
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Fen Bilimleri ve Matematik Temel Alanı
Biyoloji
Mesleki Deneyim
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2019 - ÖĞRETİM GÖREVLİSİ
PAMUKKALE ÜNİVERSİTESİ REKTÖRLÜK
İdari Görevler
Yayınlar ve Eserler
Makaleler
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Amelioration potential of synthetic oxime chemical cores against multiple sclerosis and Alzheimer's diseases: Evaluation in aspects of in silico and in vitro experiments
Journal of Molecular Structure
Özgün Makale Uluslararası
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Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent
JOURNAL OF NATURAL PRODUCTS
Özgün Makale Uluslararası
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Role of AHR, NF-kB and CYP1A1 crosstalk with the X protein of Hepatitis B virus in hepatocellular carcinoma cells
GENE
Özgün Makale Uluslararası
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Evaluation of anti-Alzheimer activity of synthetic coumarins by combination of in vitro and in silico approaches
Chemistry and Biodiversity
Özgün Makale Uluslararası
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Molecular analysis of the section Sphagnum (Sphagnaceae): first study on Turkish bryophytes using nucleotide sequences of the trnL intron region
Turkish Journal of Botany
Özgün Makale Uluslararası
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Biochemical, Pharmacological and Toxicological Attributes of Caper (Capparis ovata) Flowering Buds and Berries Pickles
Food Science & Nutrition
Özgün Makale Uluslararası
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Apatinib Sensitizes Human Breast Cancer Cells against Navitoclax and Venetoclax Despite Up-regulated Bcl-2 and Mcl-1 Gene Expressions
Turkish Journal of Oncology
Özgün Makale Uluslararası
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Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis
Journal of Translational Internal Medicine
Özgün Makale Uluslararası
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Triterpenoids and steroids isolated from Anatolian Capparis ovata and their activity on the expression of inflammatory cytokines
PHARMACEUTICAL BIOLOGY
Özgün Makale Uluslararası
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Natural diterpenoid alysine A isolated fromTeucrium alyssifoliumexertsantidiabetic effect via enhanced glucose uptake and suppressed glucose absorption
TURKISH JOURNAL OF CHEMISTRY
Özgün Makale Uluslararası
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Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3 beta-pentacosanoate for the symptomatic treatment of multiple sclerosis
FEBS Open Bio
Özgün Makale Uluslararası
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A potential therapeutic role in multiple sclerosis for stigmast-5,22-dien-3β-ol myristate isolated from Capparis ovata
The EuroBiotech Journal
Özgün Makale Uluslararası
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Association between herbivore stress and glutathione S-transferase expression in Pinus brutia Ten.
Cellular and molecular biology (Noisy-le-Grand, France)
Özgün Makale Uluslararası
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Capparis ovata treatment suppresses inflammatory cytokine expression and ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice
Journal of Neuroimmunology
Özgün Makale Uluslararası
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Modulatory actions of o-coumaric acid on carcinogen-activating cytochrome P450 isozymes and the potential for drug interactions in human hepatocarcinoma cells
PHARMACEUTICAL BIOLOGY
Özgün Makale Uluslararası
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Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells
CELL BIOLOGY AND TOXICOLOGY
Özgün Makale Uluslararası
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Cyclamen Trochopteranthum: Cytotoxic activity and possible adverse interactions including drugs and carcinogens.
Chinese journal of integrative medicine
Özgün Makale Uluslararası
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EFFECTS OF CYCLAMEN TROCHOPTERANTHUM ON HEPATIC DRUG-METABOLIZING ENZYMES
ARCHIVES OF BIOLOGICAL SCIENCES
Özgün Makale Uluslararası
Bildiriler
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Preliminary Results on Pentose Phosphate Pathway Changes in Experimental Allergic Encephalomyelitis Mice
6th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2023),
Tam metin bildiri Uluslararası
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Molecular evidence on the anti-inflammatory effect of Capparis ovata water extract (COWE) used in the treatment of multiple sclerosis
2nd International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2020),
Tam metin bildiri Uluslararası
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Kapariden (Capparis ovata) izole edilen olean-12en-28ol, 3β pentakozanoat’xxın Multipl sklerozun tedavisi için etkinliğinin değerlendirilmesi: Sentezi ve DAE modelinde ilk veriler
2. Uluslararası Türk Dünyası Multiple Skleroz Kongresi
Özet bildiri Uluslararası
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Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3b-pentacosanoate for the symptomatic treatment of multiple sclerosis.
FEBS Journal
Özet bildiri Uluslararası
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Anti-inflammatory effects of UA and OPC isolated from Capparis ovata,
7th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Anticarcinogenic effect a novel alkaloid: 1H-indole-2-hydroxy, 3 carboxylic acid
7th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Investigation of the anti-alzheimer effect of novel coumarin derivative
Turkish Journal of Biology
Özet bildiri Uluslararası
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A Toxicogenomic approach for evaluation of the nongenotoxic effects of Caper (Capparis ovata).
6th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Comparative study of te anti-inflammatory effects of sub-extracts of the Capparis ovata Extract (COWE) used as an alternative and complementary treatment for multiple sclerosis
The 3rd International Symposium on EuroAsian Biodiversity Congress
Özet bildiri Uluslararası
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promising Neuroprotective Agent for the Treatment of Multiple Sclerosis: 3-beta Hydroxyolean-12-en-28-oate Isolated from Capparis ovata
Symposium on Euro Asian Biodiversity (SEAB)
Özet bildiri Uluslararası
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Comparative study of the anti-inflammatory effects of sub-extracts of the Capparis ovata water extract (COWE) used as an alternative and complementary treatment for multiple sclerosis
Symposium on Euro Asian Biodiversity (SEAB)
Özet bildiri Uluslararası
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Stigmast-5,22-dien-3 beta-ol myristate isolated from Capparis ovata having anti-inflammatory and immunomodulatory actions could be of interest for use in multiple sclerosis
European Biotechnology Congress
Özet bildiri Uluslararası
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Analysis of 1H-indole-2-hydroxy, 3 carboxylic acid isolated from Capparis ovata for the treatment of MS: lack of evidence for the efficacy
5th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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In vitro investigation of the role of Cytochrome P4503A4 in 5-Aminosalicylic acid metabolism
5th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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In vitro investigation of the role of Cytochrome P4503A4 in 5-Aminosalicylic acid metabolism
5th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Comparative evaluation of the anti-inflammatory effect of 5-Aminosalicylic acid in Caco-2 and HepG2 cell line
5th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Multi-functional plant Capparis ovata: focusing on the antidiabetic effect
5th International Congress of the Molecular Biology Association of Turkey,
Özet bildiri Uluslararası
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Caper (Capparis ovata) water extract as an efficient preparation for treatment of multiple sclerosis
International Society of Antioxidant in NutritionandHealth (ISANH)
Özet bildiri Uluslararası
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Capparis ovata ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice
31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS)
Özet bildiri Uluslararası
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Investigation of the in vitro anticancer activities of the diterpenoid alysine B isolated from Teucrium Alyssifolium
4th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Comparative study of the anti-neuroinflammatory activities of ethyl acetate and butanolic subextracts of the water extract of Capparis ovata (MSCov).
4th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Anti-neuroinflammatory effect of ursolic acid may find application in treatment for multiple sclerosis
4th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Evaluation of antidiabetic potentinal of Circillineol using B-TC-6, 3T3-L1, C2C12 Chang Liver and Caco-2 celllines
4th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Treatment of multiple sclerosis with Capparis ovata water extract (MSCov) implicating anti-neuroinflammatory and myelinating mechanism
4th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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No obvious interaction between Cytochrome P4501A1 and Hepatitis BX.
4th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Investigation of in vitro impact of Oleonolic Acid on neuroblastoma cells (SH-SY5Y)
4th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Alterations of gene expression at the peak level in the experimental allergic encephalomyelitis
European Society of Human Genetics – ESHG
Özet bildiri Uluslararası
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Toxicogenomic analysis of Capparis ovata water extract (MSCov)
FEBS Journal
Özet bildiri Uluslararası
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Capparis ovata water extract (MSCov) for the potential treatment of multiple sclerosis without drug interaction: molecular evidences
FEBS Journal
Özet bildiri Uluslararası
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Effect of Capparis ovata water extract on the lipid metabolism used as an alternative and complemenatary treatment for multiple sclerosis
th International Congress of the Molecular Biology Association of Turkey
Özet bildiri Uluslararası
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Anti-neuroinflammatory effect of butanolic fraction of Capparis ovata water extract used as an alternative and complementary treatment for multiple sclerosis
12th International Congress of Journal of Neuroimmunology
Özet bildiri Uluslararası
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Effects of Capparis ovata on apoptotic and necrotic
Symposium on EuroAsian Biodiversity (SEAB)
Özet bildiri Uluslararası
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Low potential for drug interaction of Capparis ovata water extract.
19th International Symposium on Microsomesand Drug Oxidationsand 12thEuropean Regional ISSX Meeting
Özet bildiri Uluslararası
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Drug interaction and carcinogen activating potential of o-Coumaric Acid.
19th International Symposium on Microsomes and Drug Oxidations and 12thEuropean Regional ISSX Meeting
Özet bildiri Uluslararası
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Multipl skleroz tedavisi için olası etkin bir preparat-Capparis ovata ekstresi MSCOV: moleküler bulgular
Ulusal Biyokimya Kongresi
Özet bildiri Ulusal
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Capparis ovata (MSCOV) Sulu Özütünün Deneysel MS Modeli Üzerinde Koruyucu ve İyileştirici Etkileri
Ulusal Biyoloji Kongresi
Özet bildiri Ulusal
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Modulatory effects of Cyclamen Trochopteranthum on drug and carcinogen metabolism in HELA cells
FEBS Journal
Özet bildiri Uluslararası
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Differential effects of cyclamen extract on P450 gene expression in human hepatocarcinoma HepG2 cells
FEBS Journal
Özet bildiri Uluslararası
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Anti-cancer effect of bee venom in cervical cancer cells
FEBS Journal
Özet bildiri Uluslararası
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Bee venom induced apoptosis in human hepatocarcinoma HepG2 cells
FEBS Journal
Özet bildiri Uluslararası
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Akrilamidin insan karaciğer kanser hücre hattında (HepG2) Sitokrom P4501A1, 1A2, 2E1 ve 3A4 mRNA ekspresyon düzeylerinde olan etkisi
20. Ulusal Biyoloji Kongresi
Özet bildiri Ulusal
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Differential effects of cyclamen extract on P450 gene expression
ISSX Journal
Özet bildiri Uluslararası
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Possible implications of Cyclamen trochopterantum on human therapeutics
FEBS Journal
Özet bildiri Uluslararası
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Cyclamen as an ethnomedicine. Is it safe?
FEBS Journal
Özet bildiri Uluslararası
Kitap / Kitap Bölüm
Projeler ve Patentler
Projeler
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1 Yeni Liquorilactobacillus nagelii AGA58 Probiyotiğinin Multipl Skleroz Tedavi Etkinliğinin Mikrobiyom ve İlişkili Metabolom Değişiklikleri ve Pentoz Fosfat Yolağı Açısından Değerlendirilmesi
Yürütücü -Tübitak 1001
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2 Hematopoetik Maligniteleri Tedavi Edici Rollerine Yönelik Güncel Araştırmaların Yürütüldüğü Yeni Nesil BH3 Mimetiklerinin ve Apatinib Kombinlerinin Farklı Meme Kanseri Hücre Hatları Üzerindeki Sitotoksik ve Apoptotik Etkilerinin Araştırılması
Araştırmacı Yükseköğretim Kurumları tarafından destekli bilimsel araştırma projesi
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3 Capparis ovata’dan izole edilen olean-12-en-28-ol, 3β pentakosanoat’ın (OPC) multiplskleroz’unsemptomatik tedavisi için in vivo etkinliğinin incelenmesi (117S293)
Bursiyer -Tübitak 1001
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4 Multipl Skleroz Tedavisinde Altarnatif ve Tamamlayıcı Ajan Olarak Kullanılan Capparis Ovatadan Elde Edilen MSCOV Alt Fraksiyonlarının SH-SY5Y ve LUHMES Hücre Hatları Üzerine Etkilerinin Moleküler Mekanizmalarının Araştırılması
Araştırmacı Yükseköğretim Kurumları tarafından destekli bilimsel araştırma projesi
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5 Deneysel Multipl Skleroz Modelinde DAE MSCOV un İyileştirici Etkilerinin Moleküler Mekanizmalarının Saptanması
Araştırmacı -Tübitak 1001
Patentler
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ALAATTİN ŞEN
BİR BİLEŞİK VE BU BİLEŞİĞİ İÇEREN BİR İLAÇ
SECTION A - HUMAN NECESSITIES